Senolytics

1. Description

   Complete composition with trans-resveratrol from Japanese polygonum root extract, fisetin from Cotinus coggygria Scop. Extract, quercetin from Japanese Sophora flower extract and grape seed extract, ingredients with nutritional and physiological effects and antioxidant activity. In particular, trans-resveratrol is a polyphenol, which belongs to the class of phytoalexins and exhibits a strong antioxidant effect. 

   Fisetin belongs to the group of flavonoids and in particular to flavonols, just like quercetin, and they show antioxidant activity proven in the literature. Finally, grape seed extract is rich in antioxidant proanthocyanidins (OPC).

   EOF notification number: 6670/18-1-2024

2. Ingredients

   Suplement Facts - Serving Size 6 capsules

   • Fisetin (from Cotinus coggygria Scop. Extract) - 1500mg
   • Resveratrol (from Polygonum cuspidatum root extract) - 1000mg
   • Quercetin (from Sophora japonica L. flower extract) - 1000mg
   • Grape (Vitis vinifera) seed extract - 150mg

   Other ingredients: magnesium stearate, vegetable capsule shell (hydroxypropylmethylcellulose).

   Free from chemical excipients, artificial colourings, artificial flavors, artificial sweeteners, gluten, gmo's.

3. Benefits

   Over time and age, the body accumulates "worn out," i.e., aged cells that do not work correctly. Aging cells lose their ability to divide and function normally by releasing pro-inflammatory molecules, even affecting healthy neighboring cells.

   While the immune system can naturally remove these cells, it slowly loses effectiveness.

   The inflammatory environment created by senescent cells, in turn, leads to the senescence of more cells.

   That creates a perpetual cycle where inflammation and aging feed off each other, contributing to tissue dysfunction and age-related diseases such as cardiovascular disease, autoimmune disease, chronic liver disease, diabetes, etc.

   Senolytics are the key to reversing this process.

   Senolytics are a group of molecules that remove senescent cells by inducing apoptosis, a form of programmed cell death, in senescent cells. Most senolytics come from a class of molecules called polyphenols, found in various fruits and vegetables.

   Studies have shown that even removing 1/3 of senescent cells slows down wear and tear and the onset of age-related diseases.

   Cellular aging is a condition in which cells lose their ability to divide and function efficiently, often in response to the aging process itself, chronic inflammation, genetic factors, lack of exercise, unhealthy diet, and UV exposure.

   While antioxidants neutralize free radicals to reduce cell damage, senolytics aim to eliminate senescent cells.

   Fisetin is a natural flavonoid, a plant compound with antioxidant properties, found in various fruits and vegetables, including onions, apples, and strawberries.

   Fisetin works as a senolytic by selectively targeting and eliminating senescent cells that have stopped dividing.

   Senescent cells accumulate in tissues over time, secreting harmful inflammatory factors and enzymes that degrade tissue function.

   Research shows that by removing these cells, fisetin helps reverse the above process, slowing down the aging process.

   Studies suggest that fisetin achieves this through apoptosis, a process of programmed cell death, in worn-out, senescent cells while not affecting healthy cells.

   In animal studies, fisetin effectively prevents weight gain and adipose tissue accumulation in people on a high-fat diet.

   Quercetin belongs to a group of plant molecules known as flavonoids. These cannot be synthesized in the human body but are produced in plants to combat environmental stressors.

   Flavonoids are known for their contribution to anti-aging and longevity due to their anti-allergic, senolytic, antiviral, and anti-inflammatory properties.

   Resveratrol is a plant polyphenol that acts like quercetin as a natural defense mechanism against environmental stressors.
   
   As a powerful antioxidant, resveratrol works at the cellular level by boosting NAD+ and increasing the activity of the key NAD+ synthesizing enzyme.

   Resveratrol acts as a barrier to harsh environments in plants. Scientific evidence suggests it works similarly in humans to protect the body's cells and support healthy aging.

   Research and clinical data show that resveratrol supports bone health, cardiovascular health, blood glucose levels, healthy cognitive function, youthful skin, and oral health.

   Resveratrol can penetrate cells and help rejuvenate mitochondria, helping to support healthy aging. Mitochondria create energy inside every cell in our body.

   However, as we age, mitochondrial function slowly declines. This leads to the dysfunction of many body functions, and resveratrol helps reverse or slow down this process.

   Resveratrol's benefits for healthy aging can partially be explained by its activating sirtuins, a family of enzymes that play a significant role in DNA repair.Due to their synergistic effects, quercetin, fisetin, and resveratrol could more effectively promote cellular health and longevity than when taken separately.

   Sirtuins, a group of proteins associated with longevity and cellular health.

4. See the science

   1. Zhao R, Kou H, Jiang D, Wang F. 2023. Exploring the anti-aging effects of fisetin in telomerase-deficient progeria mouse model. PeerJ 11:e16463 http://doi.org/10.7717/peerj.16463

   2. Huard, C.A.; Gao, X.; Dey Hazra, M.E.; Dey Hazra, R.-O.; Lebsock, K.; Easley, J.T.; Millett, P.J.; Huard, J. Effects of Fisetin Treatment on Cellular Senescence of Various Tissues and Organs of Old Sheep. Antioxidants 2023, 12, 1646. https://doi.org/10.3390/antiox12081646

   3. Cui Z, Zhao X, Amevor FK, Du X, Wang Y, Li D, Shu G, Tian Y, Zhao X. Therapeutic application of quercetin in aging-related diseases: SIRT1 as a potential mechanism. Front Immunol. 2022 Jul 22;13:943321.         doi: 10.3389/fimmu.2022.943321.

   4. Deepika; Maurya, P.K. Health Benefits of Quercetin in Age-Related Diseases. Molecules 2022, 27, 2498. https://doi.org/10.3390/molecules27082498

   5. Turner, Vasu & Griffin (2019) Turner KJ, Vasu V, Griffin DK. Telomere biology and human phenotype. Cell. 2019;8:73. doi: 10.3390/cells8010073

   6. Moraes, D. S., Moreira, D. C., Andrade, J., & Santos, S. (2020). Sirtuins, brain and cognition: A review of resveratrol effects. IBRO reports, 9, 46 51. https://doi.org/10.1016/j.ibror.2020.06.004

   7. Sun, Li & Kirkland (2022) Sun Y, Li Q, Kirkland JL. Targeting senescent cells for a healthier longevity: the roadmap for an era of global aging. Life Medicine. 2022;1:103–119. doi: 10.1093/lifemedi/lnac030

   8. R. Torregrosa-Munumer, E. Vara, J. A. Fernandez-Tresguerres, and R. Gredilla, “Resveratrol supplementation at old age reverts changes associated with aging in inflammatory, oxidative and apoptotic markers in rat heart,” European Journal of Nutrition, vol. 60, no. 5, pp. 2683–2693, 2021

   9. Thaung Zaw, J. J., Howe, P. R., & Wong, R. H. (2021). Long-term effects of resveratrol on cognition, cerebrovascular function and cardio-metabolic markers in postmenopausal women: A 24-month randomised, double-blind, placebo-controlled, crossover study. Clinical nutrition (Edinburgh, Scotland), 40(3), 820–829. https://doi.org/10.1016/j.clnu.2020.08.025

   10. Van de Ven R.A., Santos D., Haigis M.C. Mitochondrial sirtuins and molecular mechanisms of aging. Trends Mol. Med. 2017;23:320–331. doi: 10.1016/j.molmed.2017.02.005

   11. Ramírez-Garza, S. L., Laveriano-Santos, E. P., Marhuenda-Muñoz, M., Storniolo, C. E., Tresserra-Rimbau, A., Vallverdú-Queralt, A., & Lamuela-Raventós, R. M. (2018). Health Effects of Resveratrol: Results from Human Intervention Trials. Nutrients, 10(12), 1892. https://doi.org/10.3390/nu10121892

   12. Sanders, J.L.; Newman, A.B. Telomere Length in Epidemiology: A Biomarker of Aging, Age-Related Disease, Both, or Neither? Epidemiol. Rev. 2013, 35, 112–1https://doi.org/10.1093/lifemedi/lnac030

   13. Lee, J. A., Ha, S. K., Cho, E., & Choi, I. (2015). Resveratrol as a Bioenhancer to Improve Anti-Inflammatory Activities of Apigenin. Nutrients, 7(11), 9650–9661. https://doi.org/10.3390/nu7115485

5. How to use

   Take 2 capsules three times daily or according to the directions of your doctor. Do not exceed the stated recommended daily dose.

6. Shipping

   Natural Doctor products are dispatched from Greece with express courier service. Shipping costs and any other taxes will be displayed during the checkout process.
   
   Please notice that for non-EU countries other taxes and import duties may be applied by your local authorities.
   
   Once the order is accepted and the stock is available, your order is dispatched within 1-2 business days, Monday through Friday.